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What we already knew getting some scientific collaboration [Nov. 20th, 2008|10:53 am]
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Just some news being passed along that makes things a bit clearer for the queerer...


Transsexual gene link identified
Australian researchers have identified a significant link between a
gene involved in testosterone action and male-to-female

DNA analysis from 112 male-to-female transsexual volunteers showed
they were more likely to have a longer version of the androgen
receptor gene.

The genetic difference may cause weaker testosterone signals, the
team reported in Biological Psychiatry.

However, other genes are also likely to play a part, they stressed.

Increasingly, biological factors are being implicated in gender

There is a social stigma that transsexualism is simply a lifestyle
choice, however our findings support a biological basis of how gender
identity develops
Professor Vincent Harley, researcher

One study has shown that certain brain structures in male-to-female
transsexual people are more "female like".

In the latest study, researchers looked for potential differences in
three genes known to be involved in sex development - coding for the
androgen receptor, the oestrogen receptor and an enzyme which
converts testosterone to oestrogen.

Comparison of the DNA from the male to female transsexual
participants with 258 controls showed a significant link with a long
version of the androgen receptor gene and transsexualism.


It is known that longer versions of the androgen receptor gene are
associated with less efficient testosterone signalling.

This reduced action of the male sex hormone may have an effect on
gender development in the womb, the researchers speculated.

"We think that these genetic differences might reduce testosterone
action and under masculinise the brain during foetal development, "
said researcher Lauren Hare from Prince Henry's Institute of Medical

Co-author Professor Vincent Harley added: "There is a social stigma
that transsexualism is simply a lifestyle choice, however our
findings support a biological basis of how gender identity develops."

Although this is the largest genetic study of transsexualism to date,
the researchers now plan to see if the results can be replicated in a
larger population.

Terry Reed from the Gender Identity Research and Education Society
said she was convinced of a biological basis to transsexualism.

"This study appears to reinforce earlier studies which have indicated
that, in some trans people, there may be a genetic trigger to the
development of an atypical gender identity.

"However, it may be just one of several routes and, although it seems
extremely likely that a biological element will always be present in
the aetiology of transsexualism, it's unlikely that developmental
pathways will be the same in all individuals. "

Story from BBC NEWS:

Published: 2008/10/26 13:01:09 GMT


[User Picture]From: anaisdjuna
2008-11-20 11:43 pm (UTC)

That's a fascinating article. Thanks for sharing :-)
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[User Picture]From: trema_slo
2008-11-21 08:54 am (UTC)
Glad you found some interest in it. Yes, good I thought. Was going to just send to a few friends but then started thinking it will get around quicker if I just made it "public".
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[User Picture]From: randomposting
2008-11-21 08:15 pm (UTC)
Awesome. =)
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[User Picture]From: trema_slo
2008-11-21 10:11 pm (UTC)
Yeah, 'bout time science got round tuit for T's.
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[User Picture]From: solitarydancer
2009-01-07 05:05 pm (UTC)
It just stands to reason that there is a gene. Any alternative thought is absurd to me.

The first time my dad met his biological mother, he was 60 years old. As I watched them interact, they had the same sense of humor, hand gestures, facial expressions, etc. It was amazing! Obviously, there was a genetic link at play. Why would it be so hard to believe that gender identity and orientation would also be genetically predisposed?

Thanks for posting!
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[User Picture]From: trema_slo
2009-01-08 06:25 pm (UTC)
Very Interesting and another form of proof in genetics. That's outstanding, really, and that you got to witness them in the manner you describe.

Believe? Yes, I am a person of Faith. So imagining 'to believe' or 'believeing in' is familiar for me. Here, the article is providing both believers and doubters an educated proof, or scientific experience leading to fact. I found it an easy way to disseminate my own belief.

Glad you enjoyed.
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